Brunno Caetano

    Visiting graduate student

    Brunno Caetano is pursuing his graduate studies with Deilson Elgui de Oliveira in Brazil, and is spending one year in the Gewurz lab for collaborative studies of EBV/host interactions in B-cell lytic replication

        Stephanie Yiu

        Rotation Student

        Prior to matriculating in the Harvard Graduate Program in Virology, Stephanie did research in Allan Chiang’s laboratory on EBV lytic reactivation in nasopharyngeal carinoma. Stephanie is pursuing proteomic analyses of EBV host-pathogen interactions.

            Yuchen Zhang

            Graduate Student

            Yuchen is purusing her graduate studies, with a focus on how host histone chaperones regulate EBV latency in EBV-transformed B-cells. Check out her preprint on BioRxiv!

                Jin Hua Liang

                Graduate Student

                Jin Hua is pursuing graduate research in the Gewurz lab. Jin Hua’s research focuses on the regulation of nucleotide metabolism and NF-kB in EBV-transformed B-cells.

                    Merrin Leong, PhD

                    Post-doctoral Fellow

                    Merrin Leong did his doctoral research at Hong Kong University in the laboratory of Maria Lung, where he studied Epstein-Barr virus infection roles in regulation of host histone modifications.  Merring identified that EBV infections induces histone bivalent switches in squameous epithelial cells, and found roles for these epigenetic modifiations in suppression of DNA damage repair genes in a methylation-independent manner.

                        Eric Burton, PhD

                        Post-doctoral Fellow

                        Eric Burton received his PhD from Stonybrook University.  Eric’s doctoral research with Sumita Bhaduri-McIntosh focused on host pathogen interactions that regulate the EBV lytic cycle.  Eric identified that EBV exploits several inflammasome sensors to activate the lytic cycle, in particular the NLRP3 inflammasome. He also identified host repressors important for the maintenance of EBV latency.

                            Rui Guo, PhD

                            Post-doctoral Fellow

                            Rui Guo received his PhD from Kansas State, where his thesis research with Ying Fan focused on procine reproductive and respiratory virus syndrome host/pathogen interactions. He discovered that PRSSV uses nanotubes for intracellular spread, that nanotubes also transfer mitochondria between nearby and infected cells, and that PRSSV RNA persists in germinal centers during persistent infection.

                              Benjamin Gewurz, MD, PhD

                              Principal Investigator

                              Ben graduated from Stanford University with as B.S. in Biological Sciences. As an undergraduate, he used bacterial genetic screens and the first whole genome sequence of a living organism to study bacterial pathogenesis with Drs. Stanley Falkow and Richard Moxon. He received a Stanford Firestone Medal for his thesis research.

                              Ben then received MD-PhD training at Harvard Medical School and MIT. His thesis studies with Hidde Ploegh and Don Wiley focused on human cytomegalovirus evasion of the MHC class I antigen presentation pathway. He solved the crystal structure of the US2/HLA-A2/Tax peptide complex at 2.2A resolution in collaboration with Rachelle Gaudet, the first atomic structure of a virus-encoded immune-evasin together with its host cell target. His thesis research was recognized by the Harvard Modell prize.

                              Ben then completed training in internal medicine at the Beth Israel Deaconess Medical Center and in infectious diseases at the Brigham & Women’s and Massachusetts General Hospitals. His post-doctoral studies with Elliott Kieff focused on Epstein-Barr virus oncoprotein LMP1-mediated canonical NF-kB pathway activation. He performed the first siRNA screen of the canonical LMP1/NF-kB pathway and identified LMP1 genome-wide canonical NF-kB targets.

                              Ben began his independent laboratory at the Brigham & Women’s in 2012. His research has been supported by the the NIH, a Burroughs Wellcome Career Award in Medical Sciences, an American Cancer Society Research Scholarship, the Starr Cancer foundation, the Grunebaum Foundation, and the Harvard Catalyst.  He has been awarded the Jeffrey Modell Prize for Harvard Graduate Program in Immunology best thesis, the Thaler Award for Research in Immunocompromised Patients, the Finland Award for Excellence in Research, the Kass Award for Excellence in Clinical Medicine, the International Herpesvirus Workshop Priscilla Schaffer Memorial Award and a Chair’s Research Award. He was elected to the American Society of Clinical Investigation in 2020.

                              Ben enjoys teaching, and received a Derek Bok teaching award for undergraduate education in immunology. He is the Associate Chair of the Harvard Virology graduate program (http://www.hms.harvard.edu/dms/virology/), and teaches in several virology program courses. He is an Associate Member of the Broad Institute of Harvard and MIT, a member of the Dana-Farber/ Harvard Cancer Center, and is on the advisory boards for the Harvard/MIT MD-PhD and Health Sciences and Technology programs. He is also a member of the Virology Editorial board. He attends on the Brigham & Women’s and Dana Farber Immunocompromised Host infectious disease inpatient consult service.

                              Email: bgewurz@bwh.harvard.edu

                              Twitter: @BenGewurz