Note: *, co-first authors;  **, co-correspondence authors.

For a complete listing of publications click here.

[2021] [2020] [2019] [2018] [2017] [2016] [2015] [2014] [2013] [2012] [2011] [2010] [2008] [2002] [2001] [2000]

2021

  • Zhang, Y., Guo, R., Kim, S., Shah, H., Zhang, S., Liang, J. H., Fang, Y., Gentili, M., Hung, D. T., Mootha, V. K. & Gewurz, B. E. SARS-CoV-2 Hijacks Folate and One-Carbon Metabolism for Viral Replication. Nature Communications 12, 1676 (2021).
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  • Gu, S. S., Zhang, W., Wang, X., Jiang, P., Traugh, N., Li, Z., Meyer, C., Stewig, B., Xie, Y., Bu, X., Manos, M. P., Font-Tello, A., Gjini, E., Lako, A., Lim, K., Conway, J., Tewari, A. K., Zeng, Z., Das Sahu, A., Tokheim, C., Weirather, J. L., Fu, J., Zhang, Y., Kroger, B., Liang, J. H., Cejas, P., Freeman, G. J., Rodig, S., Long, H. W., Gewurz, B. E., Hodi, F. S., Brown, M. & Liu, X. S. Therapeutically increasing MHC-I expression potentiates immune checkpoint blockade. Cancer Discovery (2021). doi:10.1158/2159-8290.CD-20-0812
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  • Liang, J. -H., Wang, C., Tung Yiu, S. P., Zhao, B., Guo, R. & Gewurz, B. Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-cell Growth and Survival. bioRxiv (2021). doi:10.1101/2021.01.08.426018
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  • Xia, T. -L., Li, X., Wang, X., Zhu, Y. -J., Zhang, H., Cheng, W., Chen, M. -L., Ye, Y., Li, Y., Zhang, A., Dai, D. -L., Zhu, Q. -Y., Yuan, L., Zheng, J., Huang, H., Chen, S. -Q., Xiao, Z. -W., Wang, H. -B., Roy, G., Zhong, Q., Lin, D., Zeng, Y. -X., Wang, J., Zhao, B., Gewurz, B. E., Chen, J., Zuo, Z. & Zeng, M. -S. N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay. EMBO reports n/a, e50128 (2021).
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2020

  • Zhang, Y., Jiang, C., Trudeau, S. J., Narita, Y., Zhao, B., Teng, M., Guo, R. & Gewurz, B. Histone loaders CAF1 and HIRA restrict Epstein-Barr virus B-cell lytic reactivation. bioRxiv (2020). doi:10.1101/2020.04.28.067371
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  • Dalton, T., Doubrovina, E., Pankov, D., Reynolds, Raymond Cullen, I. I. I., Scholze, H., Selvakumar, A., Vizconde, T., Savalia, B., Dyomin, V., Weigel, C., Oakes, C. C., Alonso, A., Elemento, O., Pan, H., Phillip, J. M., O'Reilly, R. J., Gewurz, B. E., Cesarman, E. & Giulino-Roth, L. Epigenetic reprogramming sensitizes immunologically silent EBV+ lymphomas to viral directed immunotherapy. Blood (2020). doi:10.1182/blood.2019004126
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  • Guo, R., Jiang, C., Zhang, Y., Govande, A., Trudeau, S. J., Chen, F., Fry, C. J., Puri, R., Wolinsky, E., Schineller, M., Frost, T. C., Gebre, M., Zhao, B., Giulino-Roth, L., Doench, J. G., Teng, M. & Gewurz, B. E. MYC Controls the Epstein-Barr Virus Lytic Switch. Molecular Cell (2020). doi:https://doi.org/10.1016/j.molcel.2020.03.025
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  • Smith, N. A., Coleman, C. B., Gewurz, B. E. & Rochford, R. CD21 (Complement Receptor 2) is the receptor for Epstein-Barr virus entry into T cells. Journal of Virology (2020). doi:10.1128/JVI.00428-20
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  • Guo, R., Zhang, Y., Teng, M., Jiang, C., Schineller, M., Zhao, B., Doench, J. G., O’Reilly, R. J., Cesarman, E., Giulino-Roth, L. & Gewurz, B. E. DNA methylation enzymes and PRC1 restrict B-cell Epstein–Barr virus oncoprotein expression. Nature Microbiology (2020). doi:10.1038/s41564-020-0724-y
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  • editorial staff,. News & Views Commentary in the journal Cancer Discovery on our manuscript "MYC Controls the Epstein-Barr Virus Lytic Switch"!. (2020).
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  • Ferrarelli, L. K. Editors Choice commentary: Therapeutic potential of EBV infection. Science Signaling 13, (2020).
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  • Zhang, Y., Jiang, C., Trudeau, S. J., Narita, Y., Zhao, B., Teng, M., Guo, R. & Gewurz, B. E. Histone Loaders CAF1 and HIRA Restrict Epstein-Barr Virus B-Cell Lytic Reactivation. mBio 11, (2020).
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2019

  • Baratta, M. G. News & Views Commentary on Virus-mediated hijack of one-carbon metabolism. Nature Reviews Cancer 19, 486--486 (2019).
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  • Wang, L. W., Wang, Z., Ersing, I., Nobre, L., Guo, R., Jiang, S., Trudeau, S., Zhao, B., Weekes, M. P. & Gewurz, B. E. Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival. PLOS Pathogens 15, 1-35 (2019).
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  • Wang, L. W., Shen, H., Nobre, L., Ersing, I., Paulo, J. A., Trudeau, S., Wang, Z., Smith, N. A., Ma, Y., Reinstadler, B., Nomburg, J., Sommermann, T., Cahir-McFarland, E., Gygi, S. P., Mootha, V. K., Weekes, M. P. & Gewurz, B. E. Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation. Cell Metabolism (2019). doi:10.1016/j.cmet.2019.06.003
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  • Jiang, C., Trudeau, S. J., Cheong, T. -C., Guo, R., Teng, M., Wang, L. W., Wang, Z., Pighi, C., Gautier-Courteille, C., Ma, Y., Jiang, S., Wang, C., Zhao, B., Paillard, L., Doench, J. G., Chiarle, R. & Gewurz, B. E. CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation. Cell Reports 28, 1307--1322.e8 (2019).
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2018

  • Wang, L. W., Trudeau, S. J., Wang, C., Gerdt, C., Jiang, S., Zhao, B. & Gewurz, B. E. Modulating Gene Expression in Epstein-Barr Virus (EBV)-Positive B Cell Lines with CRISPRa and CRISPRi. Current Protocols in Molecular Biology 121, 1-31 (2018).
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  • Jiang, S., Wang, L. W., Walsh, M. J., Trudeau, S. J., Gerdt, C., Zhao, B. & Gewurz, B. E. CRISPR/Cas9-Mediated Genome Editing in Epstein-Barr Virus-Transformed Lymphoblastoid B-Cell Lines. Current Protocols in Molecular Biology 121, (2018).
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  • Gebre, M., Nomburg, J. L. & Gewurz, B. E. CRISPR–Cas9 Genetic Analysis of Virus–Host Interactions. Viruses 10, (2018).
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  • Zhang, H., Li, Y., Wang, H. -B., Zhang, A., Chen, M. -L., Fang, Z. -X., Dong, X. -D., Li, S. -B., Du, Y., Xiong, D., He, J. -Y., Li, M. -Z., Liu, Y. -M., Zhou, A. -J., Zhong, Q., Zeng, Y. -X., Kieff, E., Zhang, Z., Gewurz, B. E., Zhao, B. & Zeng, M. -S. Ephrin receptor A2 is an epithelial cell receptor for Epstein–Barr virus entry. Nature Microbiology 3, 164--171 (2018).
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2017

  • Minamitani, T. *, Ma, Y. *, Zhou, H., Kida, H., Tsai, C. -Y., Obana, M., Okuzaki, D., Fujio, Y., Kumanogoh, A., Zhao, B., Kikutani, H., Kieff, E. **, Gewurz, B. E. ** & Yasui, T. **. Mouse model of Epstein–Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative disease. Proceedings of the National Academy of Sciences 114, 4751-4756 (2017).
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  • Ma, Y. *, Walsh, M. J. *, Bernhardt, K., Ashbaugh, C. W., Trudeau, S. J., Ashbaugh, I. Y., Jiang, S., Jiang, C., Zhao, B., Root, D. E., Doench, J. G. & Gewurz, B. E. CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors. Cell Host & Microbe 21, 580--591.e7 (2017).
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  • Ersing, I. *, Nobre, L. *, Wang, L. W., Soday, L., Ma, Y., Paulo, J. A., Narita, Y., Ashbaugh, C. W., Jiang, C., Grayson, N. E., Kieff, E., Gygi, S. P., Weekes, M. P. ** & Gewurz, B. E. **. A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells. Cell Reports 19, 1479--1493 (2017).
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  • Jiang, S., Zhou, H., Liang, J., Gerdt, C., Wang, C., Ke, L., Schmidt, S. C. S., Narita, Y., Ma, Y., Wang, S., Colson, T., Gewurz, B., Li, G., Kieff, E. & Zhao, B. The Epstein-Barr Virus Regulome in Lymphoblastoid Cells. Cell Host & Microbe 22, 561 - 573.e4 (2017).
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  • Wang, L. W., Jiang, S. & Gewurz, B. E. Epstein-Barr Virus LMP1-Mediated Oncogenicity. Journal of Virology 91, (2017).
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2016

  • Hunter, J. E., Butterworth, J. A., Zhao, B., Sellier, H., Campbell, K. J., Thomas, H. D., Bacon, C. M., Cockell, S. J., Gewurz, B. E. & Perkins, N. D. The NF-kappaB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma. Oncogene 35, 3476-3484 (2016).
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  • Blondel, C.  J., Park, J.  S., Hubbard, T.  P., Pacheco, A.  R., Kuehl, C.  J., Walsh, M.  J., Davis, B.  M., Gewurz, B.  E., Doench, J.  G. & Waldor, M.  K. CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type \III\ Secretion System-Mediated Cytotoxicity. Cell Host & Microbe 20, 226 - 237 (2016).
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2015

  • Minamitani, T., Yasui, T., Ma, Y., Zhou, H., Okuzaki, D., Tsai, C. -Y., Sakakibara, S., Gewurz, B. E., Kieff, E. & Kikutani, H. Evasion of affinity-based selection in germinal centers by Epstein–Barr virus LMP2A. Proceedings of the National Academy of Sciences 112, 11612-11617 (2015).
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  • Greenfeld, H., Takasaki, K., Walsh, M. J., Ersing, I., Bernhardt, K., Ma, Y., Fu, B., Ashbaugh, C. W., Cabo, J., Mollo, S. B., Zhou, H., Li, S. & Gewurz, B. E. TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation. PLOS Pathogens 11, 1-35 (2015).
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  • Zhou, H., Schmidt, S.  C. S., Jiang, S., Willox, B., Bernhardt, K., Liang, J., Johannsen, E.  C., Kharchenko, P., Gewurz, B.  E., Kieff, E. & Zhao, B. Epstein-Barr Virus Oncoprotein Super-enhancers Control B Cell Growth. Cell Host & Microbe 17, 205 - 216 (2015).
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2014

  • Zhao, B., Barrera, L.  A., Ersing, I., Willox, B., Schmidt, S.  C. S., Greenfeld, H., Zhou, H., Mollo, S.  B., Shi, T.  T., Takasaki, K., Jiang, S., Cahir-McFarland, E., Kellis, M., Bulyk, M.  L., Kieff, E. & Gewurz, B.  E. The NF-κB Genomic Landscape in Lymphoblastoid B Cells. Cell Reports 8, 1595 - 1606 (2014).
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  • Zhou, X., Massol, R. H., Nakamura, F., Chen, X., Gewurz, B. E., Davis, B. M., Lencer, W. I. & Waldor, M. K. Remodeling of the Intestinal Brush Border Underlies Adhesion and Virulence of an Enteric Pathogen. mBio 5, (2014).
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  • Iannetti, A., Ledoux, A. C., Tudhope, S. J., Sellier, H., Zhao, B., Mowla, S., Moore, A., Hummerich, H., Gewurz, B. E., Cockell, S. J., Jat, P. S., Willmore, E. & Perkins, N. D. Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescence. PLOS Genetics 10, 1-20 (2014).
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2013

  • Ersing, I., Bernhardt, K. & Gewurz, B. E. NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1. Viruses 5, 1587 (2013).
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  • Zhou*, X., Gewurz*, B.  E., Ritchie, J.  M., Takasaki, K., Greenfeld, H., Kieff, E., Davis, B.  M. & Waldor, M.  K. A Vibrio parahaemolyticus \T3SS\ Effector Mediates Pathogenesis by Independently Enabling Intestinal Colonization and Inhibiting \TAK1\ Activation. Cell Reports 3, 1690 - 1702 (2013).
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2012

  • Gewurz, B. E., Towfic, F., Mar, J. C., Shinners, N. P., Takasaki, K., Zhao, B., Cahir-McFarland, E. D., Quackenbush, J., Xavier, R. J. & Kieff, E. Genome-wide siRNA screen for mediators of NF-κB activation. Proceedings of the National Academy of Sciences 109, 2467-2472 (2012).
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2011

  • Gewurz, B. E., Mar, J. C., Padi, M., Zhao, B., Shinners, N. P., Takasaki, K., Bedoya, E., Zou, J. Y., Cahir-Mcfarland, E., Quackenbush, J. & Kieff, E. Canonical NF-κB Activation Is Essential for Epstein-Barr Virus Latent Membrane Protein 1 TES2/CTAR2 Gene Regulation. Journal of Virology 85, 6764-6773 (2011).
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  • Zhao, B., Mar, J. C., Maruo, S., Lee, S., Gewurz, B. E., Johannsen, E., Holton, K., Rubio, R., Takada, K., Quackenbush, J. & Kieff, E. Epstein–Barr virus nuclear antigen 3C regulated genes in lymphoblastoid cell lines. Proceedings of the National Academy of Sciences 108, 337-342 (2011).
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2010

  • Boehm, D., Gewurz, B. E., Kieff, E. & Cahir-McFarland, E. Epstein-Barr latent membrane protein 1 transformation site 2 activates NF-κB in the absence of NF-κB essential modifier residues 133–224 or 373–419. Proceedings of the National Academy of Sciences 107, 18103-18108 (2010).
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2008

  • Song, Y. -J., Izumi, K. M., Shinners, N. P., Gewurz, B. E. & Kieff, E. IRF7 activation by Epstein–Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3. Proceedings of the National Academy of Sciences 105, 18448--18453 (2008).
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2002

  • Gewurz, B. E., Ploegh, H. L. & Tortorella, D. US2, a Human Cytomegalovirus-encoded Type I Membrane Protein, Contains a Non-cleavable Amino-terminal Signal Peptide. Journal of Biological Chemistry 277, 11306-11313 (2002).
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2001

  • Gewurz, B. E., Gaudet, R., Tortorella, D., Wang, E. W. & Ploegh, H. L. Virus subversion of immunity: a structural perspective. Current Opinion in Immunology 13, 442 - 450 (2001).
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  • Gewurz, B. E., Wang, E. W., Tortorella, D., Schust, D. J. & Ploegh, H. L. Human Cytomegalovirus US2 Endoplasmic Reticulum-Lumenal Domain Dictates Association with Major Histocompatibility Complex Class I in a Locus-Specific Manner. Journal of Virology 75, 5197-5204 (2001).
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  • Gewurz, B. E., Gaudet, R., Tortorella, D., Wang, E. W., Ploegh, H. L. & Wiley, D. C. Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2. Proceedings of the National Academy of Sciences 98, 6794-6799 (2001).
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2000

  • Tortorella, D., Gewurz, B. E., Furman, M. H., Schust, D. J. & Ploegh, H. L. Viral Subversion of the Immune System. Annual Review of Immunology 18, 861-926 (2000).
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