We are located in the heart of the Harvard Medical School Longwood Medical Area at the Brigham & Women’s Hospital Division of Infectious Disease. We are also associated with the Harvard Department of Microbiology: https://micro.hms.harvard.edu/
Ben is the co-director of the Harvard Graduate Program in Virology: https://www.hms.harvard.edu/dms/virology/
We are located nearby the Broad Institute of Harvard and MIT. Dr. Gewurz is an Associate Member of the Broad:
We are looking for graduate students and postdocs interested in EBV, B-cell biology, and/or SARS-CoV-2 host/pathogen interactions to join our group. Please send inquiries to: firstname.lastname@example.org.
11.25.20 Congratulations to Yuchen for being selected as a recipient of a Broad Institute Excellence and Achievement Award for her COVID-19 research!
12.3.20. Congratulations to Stephainie Yiu on passing her graduate program qualifying exam!
12.8.20. Congratulations to Rui Guo on receiving a Lymphoma Research Foundation Post-doctoral Fellowship!
12.22.20 Congratulations Mercedes on a great 1st HMS Virology Program rotation well done during a pandemic! What a seamless transition from reovirus -> EBV.
1.2.21 Welcome to the lab Desmond for your 2nd HMS virology program rotation! Glad to have you back in the gamma-herpesvirus field!
3.14.21 Congratulations to Jinhua on finishing her graduate research in the lab! It was wonderful having you with us in the lab.
3.15.21 Glad to see our metabolomic analysis of SARS-CoV-2 infection go live @NatureComms. Looking forward to the next chapter! Great Research Brief writeup in the BWH Research Brief:
Blocking folate metabolism with oral, prophylactic drugs could reduce viral replication in infected cells. When SARS-CoV-2, the virus that causes COVID-19, infects a human cell, it quickly begins to replicate by seizing the cell’s existing metabolic machinery.
3.19.21 Glad to see the writeup of our SARS-CoV-2 work in the Broad weekly newsletter, the “Broadcast”:
SARS-CoV-2 hijacks metabolic pathways for replication
How coronaviruses, and notably SARS-CoV-2, appropriate metabolic pathways to support viral replication has remained unclear. Yuchen Zhang, Rui Guo, Sharon Kim, Hardik Shah, Shuting Zhang, Matteo Gentili, Deb Hung, Vamsi Mootha, Benjamin Gewurz, and others led a new transcriptomic and metabolomic investigation into the lifecycle of SARS-CoV-2. The team found that infected cells are low in glucose and folate, and that the virus co-opts folate and one-carbon pathways to support purine synthesis. Published in Nature Communications, the results suggest that metabolic pathway inhibitors such as methotrexate, an FDA-approved arthritis treatment, could help treat patients hospitalized with COVID-19. Learn more in a Brigham and Women’s Hospital news story.
Thanks also to medicalresearch.com for this writeup of our recent SARS-CoV-research:
3.21.21 Congratulations to Yuchen on finishing her graduate research in the lab! It was wonderful having you with us in the lab.
4.21 Looking forward to joining PLoS Pathogens as an Associate Editor! Doesn’t feel that long ago that the first manuscript was published in PLoS Pathogens in 2015.
5.6.21 Thanks to Nature Communications editors for highlighting our SARS-CoV-2 folate and one carbon manuscript, now a top 50 viewed article.
6.11.21 Welcome to SHURP summer student Jewel Voyer, visiting for the summer from University of Rhode Island!
6.13.21 Congratulations to Jin Hua and team on acceptance of our CTPS1 cytidine metabolism paper to mBio! Jin Hua arrived shortly before the pandemic, very impressed that this is out despite all the challenges!
6.15.21 Warm welcome to new post-doctoral fellows Laura Murray-Nerger and Yifei Liao.
6/18.21 Congratulations to Zhonghao, Rui, Steve, Emma and team on acceptance of our CYB561A3 iron metabolism paper to Blood! What a long but interesting journey to learn about how this little studied iron reductase has a key role in Burkitt lymphoma proliferation.
7.21 Warm welcome to Michael Lutchnekov, a new research technician in the group.
7.15.21 Excited to start work on a newly funded R01 to study mechanisms by which DNA loop extrusion regulates the EBV lytic switch in B-cells. Laura Murray-Nerger is already making new inroads!
7.21.21. Was fun to co-chair the ASV meeting session in which Rui Guo gave a brilliant talk on metabolism/epigenetic cross-talk at the level of EBV genome regulation in Burkitt lymphoma B-cells.