We are always looking for motivated graduate students and postdocs who are interested in studying EBV, B-cell immunobiology, immunometabolism, EBV-associated epithelial cancers and/or SARS-CoV-2 host/pathogen interactions to join our group. Please send inquiries to: firstname.lastname@example.org.
We are located in the heart of the Harvard Medical School Longwood Medical Area at the Brigham & Women’s Hospital Division of Infectious Disease. We are also associated with the Harvard Department of Microbiology: https://micro.hms.harvard.edu/
Ben is the co-director of the Harvard Graduate Program in Virology: https://www.hms.harvard.edu/dms/virology/
We are located nearby the Broad Institute of Harvard and MIT. Dr. Gewurz is an Associate Member of the Broad:
We are always looking for motivated graduate students and postdocs who are interested in studying EBV
Harvard Microbiology Retreat:
B-cell immunobiology, immunometabolism, EBV-associated epithelial cancers and/or SARS-CoV-2 host/pathogen interactions to join our group. Please send inquiries to: email@example.com.
11.25.20 Congratulations to Yuchen for being selected as a recipient of a Broad Institute Excellence and Achievement Award for her COVID-19 research!
12.3.20. Congratulations to Stephainie Yiu on passing her graduate program qualifying exam!
12.8.20. Congratulations to Rui Guo on receiving a Lymphoma Research Foundation Post-doctoral Fellowship!
12.22.20 Congratulations Mercedes on a great 1st HMS Virology Program rotation well done during a pandemic! What a seamless transition from reovirus -> EBV.
1.2.21 Welcome to the lab Desmond for your 2nd HMS virology program rotation! Glad to have you back in the gamma-herpesvirus field!
3.14.21 Congratulations to Jinhua on finishing her graduate research in the lab! It was wonderful having you with us in the lab.
3.15.21 Glad to see our metabolomic analysis of SARS-CoV-2 infection go live @NatureComms. Looking forward to the next chapter! Great Research Brief writeup in the BWH Research Brief:
Blocking folate metabolism with oral, prophylactic drugs could reduce viral replication in infected cells. When SARS-CoV-2, the virus that causes COVID-19, infects a human cell, it quickly begins to replicate by seizing the cell’s existing metabolic machinery.
3.19.21 Glad to see the writeup of our SARS-CoV-2 work in the Broad weekly newsletter, the “Broadcast”:
SARS-CoV-2 hijacks metabolic pathways for replication
How coronaviruses, and notably SARS-CoV-2, appropriate metabolic pathways to support viral replication has remained unclear. Yuchen Zhang, Rui Guo, Sharon Kim, Hardik Shah, Shuting Zhang, Matteo Gentili, Deb Hung, Vamsi Mootha, Benjamin Gewurz, and others led a new transcriptomic and metabolomic investigation into the lifecycle of SARS-CoV-2. The team found that infected cells are low in glucose and folate, and that the virus co-opts folate and one-carbon pathways to support purine synthesis. Published in Nature Communications, the results suggest that metabolic pathway inhibitors such as methotrexate, an FDA-approved arthritis treatment, could help treat patients hospitalized with COVID-19. Learn more in a Brigham and Women’s Hospital news story.
Thanks also to medicalresearch.com for this writeup of our recent SARS-CoV-research:
3.21.21 Congratulations to Yuchen on finishing her graduate research in the lab! It was wonderful having you with us in the lab.
4.21 Looking forward to joining PLoS Pathogens as an Associate Editor! Doesn’t feel that long ago that the first manuscript was published in PLoS Pathogens in 2015.
5.6.21 Thanks to Nature Communications editors for highlighting our SARS-CoV-2 folate and one carbon manuscript, now a top 50 viewed article.
6.21 Congratulation to Rui Guo on beginning a Lymphoma Research Foundation postdoctoral fellowship.
6.11.21 Welcome to SHURP summer student Jewel Voyer, visiting for the summer from University of Rhode Island!
6.13.21 Congratulations to Jin Hua and team on acceptance of our CTPS1 cytidine metabolism paper to mBio! Jin Hua arrived shortly before the pandemic, very impressed that this is out despite all the challenges!
6.15.21 Warm welcome to new post-doctoral fellows Laura Murray-Nerger and Yifei Liao.
6/18.21 Congratulations to Zhonghao, Rui, Steve, Emma and team on acceptance of our CYB561A3 iron metabolism paper to Blood! What a long but interesting journey to learn about how this little studied iron reductase has a key role in Burkitt lymphoma proliferation.
7.21 Warm welcome to Michael Lutchnekov, a new research technician in the group.
7.15.21 Excited to start work on a newly funded R01 to study mechanisms by which DNA loop extrusion regulates the EBV lytic switch in B-cells. Laura Murray-Nerger is already making new inroads!
7.21.21. Was fun to co-chair the ASV meeting session in which Rui Guo gave a brilliant talk on metabolism/epigenetic cross-talk at the level of EBV genome regulation in Burkitt lymphoma B-cells.
8.21 Warm Welcome To Brenda Piedras, a new research technician in the group.
8.8.21 what a fun boat trip on the Charles River!
8.21 Welcome new Harvard Virology Program Grad Students!
10.21. Congratulations to Rui Guo on his score on a K99/R00 fellowship application
11.21 Warm Welcome to Nina Beri, a new post-doctoral fellow in the lab
12.21 Congrats to Rui Guo on the publication of our review in Current Opinion in Virology
12.7.21 Big thanks to Blossom Damania, Dirk Dittmer and Micah Luftig for the generous invitation to speak at the UNC/Duke AIDS Malignancy Symposium in Chapel Hill. Was fantastic to be at a live meeting!
1.22 Congrats to Stephanie on the acceptance of our BNRF1/SMC5/6 manuscript to Cell Reports!
1.22.22 Congrats to Eric Burton on the acceptance of our EBV metabolism review in PLoS Pathogens.
4.22 Congratulations to Rui on starting his K99/R00 fellowship
4.22 Congratulations to Stephanie on being selected for an oral presentation at ASV this summer!
5.22 Fantastic presentations by Stephanie and Laura in the Boston Area Herpesvirus Symposium!
5.22.22 Congratulations to Michael on “graduation” from the lab and best of luck as he embarks upon his graduate studies at Washington University in St. Louis!
5.22 Congratulations to Stephanie Yiu for being selected to give an oral presentation at the American Society for Virology (ASV) Meeting in July and also at the International Herpesvirus Workshop! Congrats to Eric Burton on being awarded an ASV Travel Award.
6.8.22 Honored to give an oral presentation at the 3rd American Association for Cancer Research Lymphoma Symposium.
6.15.22. Fantastic piece by Eshaani Mitra in the Brigham Research News:
7.8.22 Had a great time in Falmouth, Cape Cod for the HMS Microbiology Department Retreat!
7.9.22 Congratulations to Rui Guo and team on acceptance of our methionine metabolism and EBV epigenome manuscript to Cell Metabolism!
7.15.22 Fantastic time with Stephanie, Eric and Yifei at the ASV conference in Madison. Seems that we all returned COVID-free.
7.29.22 Congratulations to Clarisel for a fantastic summer fellowship through the BWH Bridge Program. Was great to have you work in the lab closely with Laura! Congratulations also to Brenda for a very productive year in the laboratory working closely with YIn on EBV-associated gastric carcinoma. Looking forward to great things to come as you both transition to med schools.