Rui Guo, PhD

Rui Guo received his PhD from Kansas State, where his thesis research with Ying Fan focused on procine reproductive and respiratory virus syndrome host/pathogen interactions. He discovered that PRSSV uses nanotubes for intracellular spread, that nanotubes also transfer mitochondria between nearby and infected cells, and that PRSSV RNA persists in germinal centers during persistent infection. Rui pursued multiple projects in the Gewurz lab, including epigenetic regulation of the EBV lytic switch, EBV latency program selection, metabolic control of the EBV epigenome and latency program, multi-omic analysis of human B-cell activation, and SARS-CoV-2 pathogenesis with a focus on metabolic remodeling to meet virus-driven nucleotide biosynthesis demand. Rui’s work in the Gewurz lab was supported by a Lymphoma Research Foundation Fellowship and a K99/R00 Pathway to Independence Award.